Gene ID: MAB_0418

Uniprot ID: B1MFW7
Full_Name: DNA-(apurinic or apyrimidinic site) lyase
Length: 265 amino acids
Description:
DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.
Sequence:
Pfam Domains
Pfam ID Pfam Name Query Mabellini
PF00633 Helix-hairpin-helix motif
PF00730 HhH-GPD superfamily base excision DNA repair protein
PF10576 Iron-sulfur binding domain of endonuclease III
EC Characterization
EC ID EC Name Query Mabellini
4.-.-.- Lyases
4.2.-.- Lyases - Carbon-oxygen lyases
4.2.99.- Lyases - Carbon-oxygen lyases - Other carbon-oxygen lyases
4.2.99.18 DNA-(apurinic or apyrimidinic site) lyase
Model Quality Coverage Length Model Start Model End Ligand Templates Download
72.06 99.62 264 1 264 None 3n5nY , 4uobA , d1rrta3 , 3fhfA , 5an4A PDB mmCIF
68.76 79.62 211 32 242 None d1orna1 PDB mmCIF
89.28 80.75 214 32 245 None d1orna1 , d2abka_ PDB mmCIF
60.49 100.0 265 1 265 None 5kn8A , 3kntA , 1rrqA , 2xhiA , 3s6iD PDB mmCIF
Model Quality Coverage Length Model Start Model End Ligand Templates Download
70.85 80.0 212 32 243 NA: sodium ion d1p59a1 PDB mmCIF
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