PDB Structure Title Method Deposition Date Modified Date Resolution RFactor RFree pH DPI
2QO2 Human EphA3 kinase and juxtamembrane region, dephosphorylated, apo structure X-RAY DIFFRACTION 2007-07-19 2009-02-24 1.60 0.18 0.2 7.5 0.19 (0.09)
4EHE B-Raf Kinase Domain in Complex with an Aminothienopyrimidine-based Inhibitor X-RAY DIFFRACTION 2012-04-02 2013-04-24 3.30 0.22 0.3 9.0 1.91 (0.83)
3VS0 Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor N-[4-(4-amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]benzamide X-RAY DIFFRACTION 2012-04-21 2013-05-01 2.93 0.24 0.29 8.0 1.16 (0.62)
3CPB Crystal structure of the VEGFR2 kinase domain in complex with a bisamide inhibitor X-RAY DIFFRACTION 2008-03-31 2009-02-24 2.70 0.22 0.29 8.0 0.83 (0.49)
3R7O Structure of dually phosphorylated c-MET receptor kinase in complex with an MK-2461 analog X-RAY DIFFRACTION 2011-03-22 2013-01-09 2.30 0.21 0.24 7.0 0.62 (0.27)
3BE1 Dual specific bH1 Fab in complex with the extracellular domain of HER2/ErbB-2 X-RAY DIFFRACTION 2007-11-15 2011-07-13 2.90 0.24 0.28 8.0 1.03 (0.56)
1WBV IDENTIFICATION OF NOVEL P38 ALPHA MAP KINASE INHIBITORS USING FRAGMENT-BASED LEAD GENERATION. X-RAY DIFFRACTION 2004-11-05 2009-02-24 2.00 0.18 0.23 7.0 0.44 (0.19)
3CD8 X-ray Structure of c-Met with triazolopyridazine Inhibitor. X-RAY DIFFRACTION 2008-02-26 2009-02-24 2.00 0.23 0.29 7.8 0.57 (0.23)
4KSQ Crystal Structure of Human B-raf bound to a DFG-out Inhibitor 5B X-RAY DIFFRACTION 2013-05-17 2013-09-04 3.30 0.21 0.26 8.3 1.54 (0.72)
3ZXZ X-ray Structure of PF-04217903 bound to the kinase domain of c-Met X-RAY DIFFRACTION 2011-08-16 2012-10-10 1.80 0.18 0.22 4.6 0.36 (0.14)
4FAP ATOMIC STRUCTURES OF THE RAPAMYCIN ANALOGS IN COMPLEX WITH BOTH HUMAN FKBP12 AND FRB DOMAIN OF FRAP X-RAY DIFFRACTION 1999-05-06 2009-02-24 2.80 0.18 0.27 8.0 1.28 (0.50)
1P2A The structure of cyclin dependent kinase 2 (CKD2) with a trisubstituted naphthostyril inhibitor X-RAY DIFFRACTION 2003-04-15 2009-02-24 2.50 0.21 0.28 9.0 0.93 (0.39)
4LI5 EGFR-K IN COMPLEX WITH N-[3-[[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino]-4-methoxy-phenyl] Prop-2-enamide X-RAY DIFFRACTION 2013-07-02 2013-09-25 2.64 0.16 0.2 4.6 1.11 (0.33)
1PMQ The structure of JNK3 in complex with an imidazole-pyrimidine inhibitor X-RAY DIFFRACTION 2003-06-11 2009-02-24 2.20 0.23 0.26 7.0 0.61 (0.27)
1RJB Crystal Structure of FLT3 X-RAY DIFFRACTION 2003-11-19 2009-02-24 2.10 0.21 0.25 6.5 0.53 (0.23)
2W1H Fragment-Based Discovery of the Pyrazol-4-yl urea (AT9283), a Multi- targeted Kinase Inhibitor with Potent Aurora Kinase Activity X-RAY DIFFRACTION 2008-10-17 2012-05-16 2.15 0.26 0.31 0.72 (0.30)
3GXL ALK-5 kinase complex with GW857175 X-RAY DIFFRACTION 2009-04-02 2009-04-21 1.80 0.23 0.26 0.38 (0.16)
1JKL 1.6A X-RAY STRUCTURE OF BINARY COMPLEX OF A CATALYTIC DOMAIN OF DEATH-ASSOCIATED PROTEIN KINASE WITH ATP ANALOGUE X-RAY DIFFRACTION 2001-07-12 2009-02-24 1.62 0.2 0.22 7.5 0.28 (0.10)
2YN8 ephB4 kinase domain inhibitor complex X-RAY DIFFRACTION 2012-10-13 2013-10-23 2.11 0.2 0.23 7.0 0.36 (0.22)
3EFJ Structure of c-Met with pyrimidone inhibitor 7 X-RAY DIFFRACTION 2008-09-09 2009-02-24 2.60 0.24 0.29 5.0 0.91 (0.45)
4HJO Crystal structure of the inactive EGFR tyrosine kinase domain with erlotinib X-RAY DIFFRACTION 2012-10-13 2012-12-05 2.75 0.23 0.25 6.9 1.18 (0.45)
4L52 Crystal Structure of 1-(4-{4-[7-amino-2-(1,2,3-benzothiadiazol-7-yl)furo[2,3-c]pyridin-4-yl]-1H-pyrazol-1-yl}piperidin-1-yl)ethan-1-one bound to TAK1-TAB1 X-RAY DIFFRACTION 2013-06-10 2013-08-07 2.54 0.19 0.23 7.0 0.77 (0.34)
2WGJ X-RAY STRUCTURE OF PF-02341066 BOUND TO THE KINASE DOMAIN OF C-MET X-RAY DIFFRACTION 2009-04-20 2011-09-28 2.00 0.21 0.23 4.6 0.52 (0.19)
3OBG Conformational plasticity of p38 MAP kinase DFG mutants in response to inhibitor binding X-RAY DIFFRACTION 2010-08-06 2010-12-22 2.80 0.21 0.32 6.0 1.38 (0.60)
3U6I Crystal structure of c-Met in complex with pyrazolone inhibitor 58a X-RAY DIFFRACTION 2011-10-12 2012-05-23 2.10 0.21 0.26 5.0 0.67 (0.23)
3QRT CDK2 in complex with inhibitor NSK-MC2-55 X-RAY DIFFRACTION 2011-02-18 2012-08-08 1.75 0.2 0.22 7.5 0.31 (0.13)
3QKM Spirocyclic sulfonamides as AKT inhibitors X-RAY DIFFRACTION 2011-02-01 2011-04-20 2.20 0.19 0.25 7.8 0.63 (0.26)
2WMV CRYSTAL STRUCTURE OF CHECKPOINT KINASE 1 (CHK1) IN COMPLEX WITH INHIBITORS X-RAY DIFFRACTION 2009-07-03 2011-10-12 2.01 0.21 0.24 0.36 (0.20)
3ZEP Crystal Structure of JAK3 Kinase Domain in Complex with a Pyrrolopyrazine-2-phenyl Ether Inhibitor X-RAY DIFFRACTION 2012-12-06 2013-12-11 2.35 0.23 0.26 0.57 (0.32)
3PLS RON in complex with ligand AMP-PNP X-RAY DIFFRACTION 2010-11-15 2010-11-24 2.24 0.23 0.29 7.5 0.63 (0.31)
4GMY JAK2 kinase (JH1 domain) in complex with 2,6-DICHLORO-N-{2-[(CYCLOPROPYLCARBONYL)AMINO]PYRIDIN-4-YL}BENZAMIDE X-RAY DIFFRACTION 2012-08-16 2013-08-07 2.40 0.16 0.23 6.0 0.67 (0.30)
4BK5 crystal structure of the human EphA4 ectodomain in complex with human ephrin A5 (amine-methylated sample) X-RAY DIFFRACTION 2013-04-22 2013-08-21 4.00 0.31 0.32 2.60 (1.46)
2ZEJ Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase X-RAY DIFFRACTION 2007-12-13 2011-07-13 2.00 0.2 0.25 8.0 0.33 (0.20)
3PA4 X-ray crystal structure of compound 2a bound to human CHK1 kinase domain X-RAY DIFFRACTION 2010-10-18 2010-12-08 1.59 0.23 0.25 7.5 0.20 (0.11)
3W2P EGFR Kinase domain T790M/L858R mutant with compound 2 X-RAY DIFFRACTION 2012-12-03 2013-08-21 2.05 0.18 0.21 6.5 0.62 (0.18)
4HVI JAK3 kinase domain in complex with 2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid ((R)-1-methyl-2-oxo-2-piperidin-1-yl-ethyl)-amide X-RAY DIFFRACTION 2012-11-06 2013-01-30 2.40 0.24 0.3 6.0 0.86 (0.38)
3ZC5 X-ray Structure of c-Met kinase in complex with inhibitor (S)-6-(1-(6- (1-methyl-1H-pyrazol-4-yl)-(1,2,4)triazolo(4,3-b)pyridazin-3-yl)ethyl) quinoline. X-RAY DIFFRACTION 2012-11-15 2013-11-27 2.20 0.2 0.26 4.6 0.61 (0.26)
2YDJ Discovery of Checkpoint Kinase Inhibitor AZD7762 by Structure Based Design and Optimization of Thiophene Carboxamide Ureas X-RAY DIFFRACTION 2011-03-22 2013-03-27 1.85 0.23 0.27 0.38 (0.18)
4ERW CDK2 in complex with staurosporine X-RAY DIFFRACTION 2012-04-20 2012-10-03 2.00 0.2 0.24 7.5 0.48 (0.20)
3LJ3 PI3-kinase-gamma with a pyrrolopyridine-benzofuran inhibitor X-RAY DIFFRACTION 2010-01-25 2012-02-29 2.43 0.22 0.26 8.6 0.82 (0.34)
2FAP THE STRUCTURE OF THE IMMUNOPHILIN-IMMUNOSUPPRESSANT FKBP12-(C16)-ETHOXY RAPAMYCIN COMPLEX INTERACTING WITH HUMA X-RAY DIFFRACTION 1998-09-22 2013-09-18 2.20 0.2 0.27 8.5 0.58 (0.27)
4FSR Crystal Structure of the CHK1 X-RAY DIFFRACTION 2012-06-27 2012-08-22 2.50 0.18 0.2 7.5 0.47 (0.28)
4H3P Crystal structure of human ERK2 complexed with a MAPK docking peptide X-RAY DIFFRACTION 2012-09-14 2013-06-26 2.30 0.18 0.22 6.5 0.40 (0.25)
2ZOQ Structural dissection of human mitogen-activated kinase ERK1 X-RAY DIFFRACTION 2008-06-01 2009-04-07 2.39 0.25 0.27 7.5 0.66 (0.33)
3UG1 Crystal structure of the mutated EGFR kinase domain (G719S/T790M) in the apo form X-RAY DIFFRACTION 2011-11-02 2014-03-12 2.75 0.2 0.24 7.1 1.42 (0.43)
1H4L STRUCTURE AND REGULATION OF THE CDK5-P25(NCK5A) COMPLEX X-RAY DIFFRACTION 2001-05-11 2009-02-24 2.65 0.24 0.29 7.6 1.00 (0.47)
3FLS P38 kinase crystal structure in complex with 6-(2,4-Difluoro-phenoxy)-2-((R)-2-methanesulfonyl-1-methyl-ethylamino)-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one X-RAY DIFFRACTION 2008-12-19 2009-12-22 2.30 0.25 0.29 7.6 0.81 (0.33)
1XBA Crystal structure of apo syk tyrosine kinase domain X-RAY DIFFRACTION 2004-08-30 2009-02-24 2.00 0.23 0.28 8.5 0.47 (0.22)
2VTH IDENTIFICATION OF N-(4-PIPERIDINYL)-4-(2,6-DICHLOROBENZOYLAMINO)-1H-PYRAZOLE-3-CARBOXAMIDE (AT7519), A NOVEL CYCLIN DEPENDENT KINASE INHIBITOR USING FRAGMENT-BASED X-RAY CRYSTALLOGRAPHY AND STRUCTURE BASED DRUG DESIGN X-RAY DIFFRACTION 2008-05-15 2010-11-03 1.90 0.2 0.24 6.7 0.42 (0.17)
4DLI Human p38 MAP kinase in complex with RL87 X-RAY DIFFRACTION 2012-02-06 2013-01-23 1.91 0.22 0.25 6.0 0.40 (0.18)
3OWL Human CK2 catalytic domain in complex with a benzopyridoindole derivative inhibitor X-RAY DIFFRACTION 2010-09-20 2011-01-05 2.10 0.2 0.27 7.5 0.49 (0.24)
3UP7 Aurora A in complex with YL1-038-09 X-RAY DIFFRACTION 2011-11-17 2012-09-26 3.05 0.23 0.29 7.5 1.97 (0.67)
3DK3 Crystal structure of mutant ABL kinase domain in complex with small molecule fragment X-RAY DIFFRACTION 2008-06-24 2009-02-24 2.02 0.21 0.25 5.6 0.40 (0.20)
3EG0 Crystal structure of the N114T mutant of ABL-SH3 domain X-RAY DIFFRACTION 2008-09-10 2011-07-13 2.30 0.22 0.28 7.0 0.83 (0.32)
2C3L IDENTIFICATION OF A BURIED POCKET FOR POTENT AND SELECTIVE INHIBITION OF CHK1: PREDICTION AND VERIFICATION X-RAY DIFFRACTION 2005-10-10 2009-02-24 2.35 0.18 0.28 7.5 0.63 (0.34)
1ZYS Co-crystal structure of Checkpoint Kinase Chk1 with a pyrrolo-pyridine inhibitor X-RAY DIFFRACTION 2005-06-10 2009-02-24 1.70 0.23 0.26 0.26 (0.14)
2X81 STRUCTURE OF AURORA A IN COMPLEX WITH MLN8054 X-RAY DIFFRACTION 2010-03-05 2011-08-31 2.91 0.24 0.3 7.6 1.72 (0.62)
2C6L CRYSTAL STRUCTURE OF THE HUMAN CDK2 COMPLEXED WITH THE TRIAZOLOPYRIMIDINE INHIBITOR X-RAY DIFFRACTION 2005-11-10 2009-02-24 2.30 0.18 0.28 7.2 0.90 (0.32)
3FI3 Crystal structure of JNK3 with indazole inhibitor, SR-3737 X-RAY DIFFRACTION 2008-12-10 2009-06-23 2.20 0.18 0.25 5.5 0.77 (0.25)
4B7T Glycogen Synthase Kinase 3 Beta complexed with Axin Peptide and Leucettine L4 X-RAY DIFFRACTION 2012-08-22 2013-01-30 2.77 0.2 0.24 1.18 (0.43)
2B52 Human cyclin dependent kinase 2 (CDK2) complexed with DPH-042562 X-RAY DIFFRACTION 2005-09-27 2009-02-24 1.88 0.22 0.28 7.4 0.50 (0.19)
3R02 The discovery of novel benzofuran-2-carboxylic acids as potent Pim-1 inhibitors X-RAY DIFFRACTION 2011-03-07 2011-05-11 1.95 0.17 0.19 6.4 0.35 (0.14)
4F5B Triple mutant Src SH2 domain bound to phosphotyrosine X-RAY DIFFRACTION 2012-05-12 2012-10-03 1.57 0.2 0.23 7.6 0.31 (0.10)
3Q9Y Crystal structure of human CK2 alpha in complex with Quinalizarin at pH 8.5 X-RAY DIFFRACTION 2011-01-10 2012-01-11 1.80 0.18 0.24 8.5 0.32 (0.15)
4AW0 Human PDK1 Kinase Domain in Complex with Allosteric Compound PS182 Bound to the PIF-Pocket X-RAY DIFFRACTION 2012-05-30 2012-10-10 1.43 0.17 0.19 7.5 0.16 (0.07)
2VWU EPHB4 KINASE DOMAIN INHIBITOR COMPLEX X-RAY DIFFRACTION 2008-06-27 2009-02-24 2.00 0.17 0.21 7.5 0.31 (0.17)
1QLY NMR STUDY OF THE SH3 DOMAIN FROM BRUTON'S TYROSINE KINASE, 20 STRUCTURES SOLUTION NMR 1999-09-20 2009-02-24
3EQD X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a binary complex with ATP-GS and MG2P X-RAY DIFFRACTION 2008-09-30 2011-07-13 2.10 0.21 8.0
3WAR Crystal structure of human CK2a X-RAY DIFFRACTION 2013-05-07 2013-10-30 1.04 0.14 0.17 8.0 0.08 (0.03)
2QKQ Structure of the SAM Domain of Human Ephrin Type-B Receptor 4 X-RAY DIFFRACTION 2007-07-11 2009-02-24 2.10 0.22 0.24 6.4 0.49 (0.22)
2Y6O Crystal structure of EphA4 kinase domain in complex with Dasatinib. X-RAY DIFFRACTION 2011-01-25 2012-01-11 1.54 0.18 0.2 6.5 0.20 (0.08)
1O4N CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH OXALIC ACID. X-RAY DIFFRACTION 2003-06-15 2009-02-24 1.60 0.21 5.5
2EDQ Solution structure of the ig-like domain (3713-3806) of human obscurin SOLUTION NMR 2007-02-14 2009-02-24
2J90 CRYSTAL STRUCTURE OF HUMAN ZIP KINASE IN COMPLEX WITH A TETRACYCLIC PYRIDONE INHIBITOR (PYRIDONE 6) X-RAY DIFFRACTION 2006-10-31 2011-07-13 2.00 0.18 0.22 8.0 0.48 (0.18)
4BIE Crystal Structures of Ask1-inhibitor Complexes X-RAY DIFFRACTION 2013-04-10 2013-08-07 2.36 0.21 0.25 6.5 0.90 (0.31)
3Q4U Crystal structure of the ACVR1 kinase domain in complex with LDN-193189 X-RAY DIFFRACTION 2010-12-24 2011-02-09 1.82 0.16 0.22 5.0 0.30 (0.14)
2ZYB Crystal structure of phenylimidazo pyrazin 2 bound to the kinase domain of human LCK, (auto-phosphorylated on TYR394) X-RAY DIFFRACTION 2009-01-19 2009-02-03 2.55 0.17 0.29 6.5 1.08 (0.43)
2GHM Mutated MAP kinase P38 (Mus Musculus) in complex with Inhbitor PG-895449 X-RAY DIFFRACTION 2006-03-27 2009-02-24 2.35 0.23 0.32 6.5 0.96 (0.39)
2L6W PDGFR beta-TM SOLUTION NMR 2010-11-29 2014-02-05
3LCT Crystal Structure of the Anaplastic Lymphoma Kinase Catalytic Domain X-RAY DIFFRACTION 2010-01-11 2010-09-08 2.10 0.2 0.26 8.0 0.58 (0.23)
2C5Y DIFFERENTIAL BINDING OF INHIBITORS TO ACTIVE AND INACTIVE CDK2 PROVIDES INSIGHTS FOR DRUG DESIGN X-RAY DIFFRACTION 2005-11-03 2009-02-24 2.25 0.17 0.29 6.6 0.82 (0.32)
3OXZ Crystal structure of ABL kinase domain bound with a DFG-out inhibitor AP24534 X-RAY DIFFRACTION 2010-09-22 2010-12-22 2.20 0.22 0.26 8.5 0.49 (0.27)
4F9B Human CDC7 kinase in complex with DBF4 and PHA767491 X-RAY DIFFRACTION 2012-05-18 2012-12-12 2.50 0.19 0.24 7.5 0.70 (0.34)
2WTV AURORA-A INHIBITOR STRUCTURE X-RAY DIFFRACTION 2009-09-22 2010-04-21 2.40 0.16 0.21 0.47 (0.27)
4BKF crystal structure of the human EphA4 ectodomain in complex with human ephrinB3 X-RAY DIFFRACTION 2013-04-24 2013-08-21 4.65 0.33 0.35 4.97 (2.32)
2XJ2 PROTEIN KINASE PIM-1 IN COMPLEX WITH SMALL MOLECULE INHIBITOR X-RAY DIFFRACTION 2010-07-01 2011-03-16 2.20 0.17 0.2 5.75 0.51 (0.21)
3GU4 Crystal structure of DAPKQ23V-AMPPNP X-RAY DIFFRACTION 2009-03-28 2010-03-09 1.35 0.18 0.21 6.5 0.17 (0.06)
3HEG P38 in complex with Sorafenib X-RAY DIFFRACTION 2009-05-08 2012-10-03 2.20 0.24 0.31 6.0 0.72 (0.32)
3IPH Crystal structure of p38 in complex with a biphenylamide inhibitor X-RAY DIFFRACTION 2009-08-17 2011-07-13 2.10 0.18 0.25 6.5 0.52 (0.23)
4LGD Structural Basis for Autoactivation of Human Mst2 Kinase and Its Regulation by RASSF5 X-RAY DIFFRACTION 2013-06-27 2013-10-30 3.05 0.2 0.24 1.03 (0.56)
3MW1 p38 kinase Crystal structure in complex with small molecule inhibitor X-RAY DIFFRACTION 2010-05-05 2011-12-07 2.80 0.26 0.34 6.5 1.30 (0.63)
2ETZ The NMR minimized average structure of the Itk SH2 domain bound to a phosphopeptide SOLUTION NMR 2005-10-27 2009-02-24
4FHJ Crystal Structure of PI3K-gamma in Complex with Imidazopyridine 2 X-RAY DIFFRACTION 2012-06-06 2012-08-29 2.60 0.21 0.25 7.8 0.82 (0.39)
1F3M CRYSTAL STRUCTURE OF HUMAN SERINE/THREONINE KINASE PAK1 X-RAY DIFFRACTION 2000-06-05 2009-02-24 2.30 0.24 0.26 6.5 0.54 (0.29)
3FMN P38 kinase crystal structure in complex with RO2530 X-RAY DIFFRACTION 2008-12-22 2011-07-13 1.90 0.2 0.24 7.6 0.37 (0.17)
3DBS Structure of PI3K gamma in complex with GDC0941 X-RAY DIFFRACTION 2008-06-02 2011-07-13 2.80 0.22 0.26 7.2 1.08 (0.49)
2WIP STRUCTURE OF CDK2-CYCLIN A COMPLEXED WITH 8-ANILINO-1-METHYL-4,5-DIHYDRO- 1H-PYRAZOLO[4,3-H] QUINAZOLINE-3-CARBOXYLIC ACID X-RAY DIFFRACTION 2009-05-14 2012-10-10 2.80 0.22 0.26 1.27 (0.48)
4L0N Crystal structure of STK3 (MST2) SARAH domain X-RAY DIFFRACTION 2013-05-31 2013-06-19 1.40 0.16 0.21 4.9 0.21 (0.07)
3ZEW Crystal structure of EphB4 in complex with staurosporine X-RAY DIFFRACTION 2012-12-07 2014-04-09 2.50 0.24 0.28 0.68 (0.40)
3DJ5 Crystal structure of the mouse Aurora-A catalytic domain (Asn186->Gly, Lys240->Arg, Met302->Leu) in complex with Compound 290. X-RAY DIFFRACTION 2008-06-22 2009-05-05 1.80 0.21 0.24 5.6 0.43 (0.15)