PDB Structure Title Method Deposition Date Modified Date Resolution RFactor RFree pH DPI
2RG6 Phenylalanine pyrrolotriazine p38 alpha map kinase inhibitor compound 11J X-RAY DIFFRACTION 2007-10-02 2009-02-24 1.72 0.2 0.22 0.27 (0.12)
3VQU CRYSTAL STRUCTURE OF HUMAN MPS1 CATALYTIC DOMAIN IN COMPLEX WITH 4-[(4-amino-5-cyano-6-ethoxypyridin-2- yl)amino]benzamide X-RAY DIFFRACTION 2012-03-30 2012-06-27 2.40 0.25 0.28 6.0 0.81 (0.36)
4FV2 Crystal Structure of the ERK2 complexed with EK5 X-RAY DIFFRACTION 2012-06-29 2012-08-29 2.00 0.18 0.21 6.5 0.33 (0.17)
1B55 PH DOMAIN FROM BRUTON'S TYROSINE KINASE IN COMPLEX WITH INOSITOL 1,3,4,5-TETRAKISPHOSPHATE X-RAY DIFFRACTION 1999-01-12 2011-11-16 2.40 0.23 0.35 4.9 1.23 (0.44)
2K7A Ensemble Structures of the binary complex between the SH3 and SH2 domain of interleukin-2 tyrosine kinase. SOLUTION NMR 2008-08-08 2009-03-10
3LOH Structure of the insulin receptor ectodomain, including ct peptide X-RAY DIFFRACTION 2010-02-03 2010-04-28 3.80 0.23 0.28 7.5 2.13 (1.14)
1I44 CRYSTALLOGRAPHIC STUDIES OF AN ACTIVATION LOOP MUTANT OF THE INSULIN RECEPTOR TYROSINE KINASE X-RAY DIFFRACTION 2001-02-19 2009-02-24 2.40 0.21 0.27 7.5 0.72 (0.34)
2D9Z Solution structure of the PH domain of Protein kinase C, nu type from human SOLUTION NMR 2005-12-13 2009-02-24
2M59 Spatial structure of dimeric VEGFR2 membrane domain in DPC micelles SOLUTION NMR 2013-02-19 2014-03-12
2BIY STRUCTURE OF PDK1-S241A MUTANT KINASE DOMAIN X-RAY DIFFRACTION 2005-01-26 2009-02-24 1.95 0.18 0.23 7.5 0.46 (0.17)
3KEX Crystal structure of the catalytically inactive kinase domain of the human epidermal growth factor receptor 3 (HER3) X-RAY DIFFRACTION 2009-10-26 2010-02-02 2.80 0.24 0.28 8.5 1.12 (0.53)
4BN1 Crystal structure of V174M mutant of Aurora-A kinase X-RAY DIFFRACTION 2013-05-13 2014-03-26 2.50 0.19 0.24 1.01 (0.34)
2XIY PROTEIN KINASE PIM-1 IN COMPLEX WITH FRAGMENT-2 FROM CRYSTALLOGRAPHIC FRAGMENT SCREEN X-RAY DIFFRACTION 2010-07-01 2011-03-16 2.20 0.17 0.2 5.5 0.51 (0.20)
2QR7 2.0A X-ray structure of C-terminal kinase domain of p90 ribosomal S6 kinase 2: Se-Met derivative X-RAY DIFFRACTION 2007-07-27 2011-07-13 2.00 0.2 0.24 7.0 0.51 (0.19)
2Z8C Phosphorylated insulin receptor tyrosine kinase in complex with (4-{[5-carbamoyl-4-(3-methylanilino)pyrimidin-2-yl]amino}phenyl)acetic acid X-RAY DIFFRACTION 2007-09-05 2009-02-24 3.25 0.22 0.29 1.91 (0.79)
3D7U Structural basis for the recognition of c-Src by its inactivator Csk X-RAY DIFFRACTION 2008-05-21 2013-09-18 4.11 0.29 0.3 2.05 (1.47)
4HJO Crystal structure of the inactive EGFR tyrosine kinase domain with erlotinib X-RAY DIFFRACTION 2012-10-13 2012-12-05 2.75 0.23 0.25 6.9 1.18 (0.45)
4EIH Crystal structure of Arg SH2 domain X-RAY DIFFRACTION 2012-04-05 2013-04-10 1.20 0.16 0.18 8.5 0.15 (0.04)
3BV3 Morpholino pyrrolotriazine P38 Alpha Map Kinase inhibitor compound 2 X-RAY DIFFRACTION 2008-01-04 2009-02-24 2.59 0.19 0.28 6.0 0.95 (0.44)
4ANV Complexes of PI3Kgamma with isoform selective inhibitors. X-RAY DIFFRACTION 2012-03-22 2012-06-27 2.13 0.24 0.3 7.2 0.65 (0.28)
1FGI CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF FIBROBLAST GROWTH FACTOR RECEPTOR 1 IN COMPLEX WITH SU5402 INHIBITOR X-RAY DIFFRACTION 1997-03-22 2009-02-24 2.50 0.19 0.27 6.5 0.96 (0.38)
3FXW High resolution crystal structure of mitogen-activated protein kinase-activated protein kinase 3/inhibitor 2 complex X-RAY DIFFRACTION 2009-01-21 2011-07-13 2.00 0.23 0.28 5.0 0.50 (0.22)
3SW7 Crystal Structure of the CDK2 in complex with thiazolylpyrimidine inhibitor X-RAY DIFFRACTION 2011-07-13 2013-05-29 1.80 0.18 0.22 7.8 0.31 (0.13)
1M61 Crystal structure of the apo SH2 domains of ZAP-70 X-RAY DIFFRACTION 2002-07-11 2009-02-24 2.50 0.24 0.29 8.0 0.73 (0.40)
4JQ7 Crystal structure of EGFR kinase domain in complex with compound 2a X-RAY DIFFRACTION 2013-03-20 2013-06-19 2.73 0.21 0.24 7.0 1.40 (0.41)
4FTK Crystal Structure of the CHK1 X-RAY DIFFRACTION 2012-06-27 2012-08-22 2.30 0.17 0.21 7.5 0.40 (0.23)
2WMU CRYSTAL STRUCTURE OF CHECKPOINT KINASE 1 (CHK1) IN COMPLEX WITH INHIBITORS X-RAY DIFFRACTION 2009-07-03 2011-10-12 2.60 0.23 0.26 0.52 (0.40)
3R7O Structure of dually phosphorylated c-MET receptor kinase in complex with an MK-2461 analog X-RAY DIFFRACTION 2011-03-22 2013-01-09 2.30 0.21 0.24 7.0 0.62 (0.27)
1GIH HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE CDK4 INHIBITOR X-RAY DIFFRACTION 2001-02-06 2009-02-24 2.80 0.17 0.28 7.2 1.28 (0.51)
3OC1 Conformational plasticity of p38 MAP kinase DFG motif mutants in response to inhibitor binding X-RAY DIFFRACTION 2010-08-09 2010-12-22 2.59 0.22 0.3 6.0 1.06 (0.46)
4JX7 Crystal structure of Pim1 kinase in complex with inhibitor 2-[(trans-4-aminocyclohexyl)amino]-4-{[3-(trifluoromethyl)phenyl]amino}pyrido[4,3-d]pyrimidin-5(6H)-one X-RAY DIFFRACTION 2013-03-27 2013-08-28 6.5
2BZI CRYSTAL STRUCTURE OF THE HUMAN PIM1 IN COMPLEX WITH A RUTHENIUM ORGANOMETALLIC LIGAND RU2 X-RAY DIFFRACTION 2005-08-18 2011-07-13 1.90 0.22 0.27 0.48 (0.19)
3E7V Crystal Structure of Human Haspin with a pyrazolo-pyrimidine ligand X-RAY DIFFRACTION 2008-08-19 2011-07-13 2.00 0.17 0.22 7.0 0.38 (0.18)
2J9M CRYSTAL STRUCTURE OF CDK2 IN COMPLEX WITH MACROCYCLIC AMINOPYRIMIDINE X-RAY DIFFRACTION 2006-11-13 2009-02-24 2.50 0.21 0.29 7.8 1.03 (0.41)
3D15 Crystal structure of mouse Aurora A (Asn186->Gly, Lys240->Arg, Met302->Leu) in complex with 1-(3-chloro-phenyl)-3-{5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)- ethyl]-thiazol-2-yl}-urea [SNS-314] X-RAY DIFFRACTION 2008-05-04 2013-06-19 2.30 0.23 0.29 1.06 (0.33)
3FKO P38 kinase crystal structure in complex with RO3668 X-RAY DIFFRACTION 2008-12-17 2011-07-13 2.00 0.21 0.25 7.6 0.43 (0.20)
4G6N Crystal Structure of the ERK2 X-RAY DIFFRACTION 2012-07-19 2012-09-19 2.00 0.19 0.23 6.5 0.34 (0.18)
3PUC Atomic resolution structure of titin domain M7 X-RAY DIFFRACTION 2010-12-04 2011-12-21 0.96 0.12 0.14 8.0 0.04 (0.02)
3KF4 Structural analysis of DFG-in and DFG-out dual Src-Abl inhibitors sharing a common vinyl purine template X-RAY DIFFRACTION 2009-10-27 2010-09-01 1.90 0.2 0.24 8.5 0.36 (0.17)
1MQB Crystal Structure of Ephrin A2 (ephA2) Receptor Protein Kinase X-RAY DIFFRACTION 2002-09-16 2009-02-24 2.30 0.24 0.29 7.5 0.83 (0.33)
3QD3 Phosphoinositide-Dependent Kinase-1 (PDK1) kinase domain with 1,1-Dimethylethyl {(3R,6S)-1-[2-amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-6-methyl-3-piperidinyl}carbamate X-RAY DIFFRACTION 2011-01-17 2011-03-30 2.00 0.18 0.21 9.0 0.42 (0.17)
3NZU Structure-based Optimization of Pyrazolo -Pyrimidine and -Pyridine Inhibitors of PI3-Kinase X-RAY DIFFRACTION 2010-07-16 2010-12-29 2.60 0.21 0.24 8.5 0.78 (0.37)
1AYC CRYSTAL STRUCTURES OF PEPTIDE COMPLEXES OF THE AMINO-TERMINAL SH2 DOMAIN OF THE SYP TYROSINE PHOSPHATASE X-RAY DIFFRACTION 1994-05-15 2009-02-24 2.30 0.19
3ZSI X-ray structure of p38alpha bound to VX-745 X-RAY DIFFRACTION 2011-06-28 2012-08-15 2.40 0.23 0.27 6.5 0.78 (0.34)
4FA2 Human P38 alpha Mitogen-Activated Kinase In Complex With SB239063 X-RAY DIFFRACTION 2012-05-21 2013-07-24 2.00 0.17 0.21 5.5 0.41 (0.17)
1WH4 Solution structure of the DEATH domain of Interleukin-1 receptor-associated kinase4 (IRAK4) from Mus musculus SOLUTION NMR 2004-05-28 2009-02-24
1NVR The Complex Structure Of Checkpoint Kinase Chk1/Staurosporine X-RAY DIFFRACTION 2003-02-04 2009-02-24 1.80 0.19 0.23 7.5 0.24 (0.14)
3BHT Structure of phosphorylated Thr160 CDK2/cyclin A in complex with the inhibitor meriolin 3 X-RAY DIFFRACTION 2007-11-29 2011-07-13 2.00 0.18 0.22 7.0 0.39 (0.18)
1GZK MOLECULAR MECHANISM FOR THE REGULATION OF PROTEIN KINASE B/ AKT BY HYDROPHOBIC MOTIF PHOSPHORYLATION X-RAY DIFFRACTION 2002-05-23 2009-02-24 2.30 0.25 0.32 7.5 0.90 (0.36)
3GCQ Human P38 MAP kinase in complex with RL45 X-RAY DIFFRACTION 2009-02-22 2009-09-29 2.00 0.22 0.27 5.9 0.48 (0.22)
3VS2 Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor 7-[cis-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine X-RAY DIFFRACTION 2012-04-21 2013-05-01 2.61 0.23 0.28 8.0 0.68 (0.43)
4FJY Crystal structure of PI3K-gamma in complex with quinoline-indoline inhibitor 24f X-RAY DIFFRACTION 2012-06-12 2012-10-24 2.90 0.2 0.27 7.3 1.18 (0.56)
4C58 Structure of GAK kinase in complex with nanobody (NbGAK_4) X-RAY DIFFRACTION 2013-09-10 2013-10-09 2.16 0.18 0.24 7.5 0.56 (0.24)
2QOD Human EphA3 kinase and juxtamembrane region, Y602F mutant X-RAY DIFFRACTION 2007-07-20 2009-02-24 1.15 0.19 0.21 7.5 0.08 (0.04)
3RNY Crystal structure of human RSK1 C-terminal kinase domain X-RAY DIFFRACTION 2011-04-24 2012-08-29 2.70 0.19 0.24 7.5 0.67 (0.41)
4AN9 Crystal structures of human MEK1 with carboxamide-based allosteric inhibitor XL518 (GDC-0973), or related analogs. X-RAY DIFFRACTION 2012-03-16 2012-12-19 2.80 0.2 0.31 8.9 1.54 (0.58)
3OY1 Highly Selective c-Jun N-Terminal Kinase (JNK) 2 and 3 Inhibitors with In Vitro CNS-like Pharmacokinetic Properties X-RAY DIFFRACTION 2010-09-22 2011-08-17 1.70 0.26 0.3 7.5 0.54 (0.16)
1DM2 HUMAN CYCLIN-DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR HYMENIALDISINE X-RAY DIFFRACTION 1999-12-13 2009-02-24 2.10 0.19 0.27 7.4 0.57 (0.24)
3DDP Structure of phosphorylated Thr160 CDK2/cyclin A in complex with the inhibitor CR8 X-RAY DIFFRACTION 2008-06-06 2009-02-24 2.70 0.21 0.27 7.0 0.96 (0.46)
2I40 Cdk2/Cyclin A complexed with a thiophene carboxamide inhibitor X-RAY DIFFRACTION 2006-08-21 2011-07-13 2.80 0.19 0.22 6.7 1.13 (0.41)
4O0V Back pocket flexibility provides group-II PAK selectivity for type 1 kinase inhibitors X-RAY DIFFRACTION 2013-12-14 2014-02-26 2.80 0.2 0.25 8.3 1.17 (0.47)
3L17 Discovery of (thienopyrimidin-2-yl)aminopyrimidines as Potent, Selective, and Orally Available Pan-PI3-Kinase and Dual Pan-PI3-Kinase/mTOR Inhibitors for the Treatment of Cancer X-RAY DIFFRACTION 2009-12-10 2011-07-13 3.00 0.22 0.27 8.5 1.28 (0.60)
4EC9 Crystal structure of full-length cdk9 in complex with cyclin t X-RAY DIFFRACTION 2012-03-26 2013-01-02 3.21 0.2 0.23 6.2 1.46 (0.61)
1O4Q CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU79256. X-RAY DIFFRACTION 2003-06-15 2009-02-24 1.70 0.18 5.5
2VWX EPHB4 KINASE DOMAIN INHIBITOR COMPLEX X-RAY DIFFRACTION 2008-06-27 2009-11-10 1.65 0.17 0.21 7.5 0.27 (0.10)
1K40 crystal structure of the FAT domain of focal adhesion kinase X-RAY DIFFRACTION 2001-10-04 2009-02-24 2.25 0.24 0.29 7.0 0.77 (0.32)
2NPT Crystal Structure of the complex of human mitogen activated protein kinase kinase 5 phox domain (MAP2K5-phox) with human mitogen activated protein kinase kinase kinase 2 phox domain (MAP3K2-phox) X-RAY DIFFRACTION 2006-10-30 2011-07-13 1.75 0.2 0.25 8.5 0.34 (0.14)
3A62 Crystal structure of phosphorylated p70S6K1 X-RAY DIFFRACTION 2009-08-18 2010-03-02 2.35 0.23 0.27 8.5 0.87 (0.33)
3EFK Structure of c-Met with pyrimidone inhibitor 50 X-RAY DIFFRACTION 2008-09-09 2009-02-24 2.20 0.26 0.29 5.0 0.61 (0.30)
2EXM Human CDK2 in complex with isopentenyladenine X-RAY DIFFRACTION 2005-11-08 2009-02-24 1.80 0.2 0.27 7.4 0.46 (0.17)
3CE3 Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor C-MET in complex with a Pyrrolopyridinepyridone based inhibitor X-RAY DIFFRACTION 2008-02-28 2009-02-24 2.40 0.21 0.28 7.1 0.89 (0.35)
3VS4 Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor 5-(4-phenoxyphenyl)-7-(tetrahydro-2H-pyran-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine X-RAY DIFFRACTION 2012-04-21 2013-05-01 2.75 0.2 0.26 8.0 0.73 (0.47)
1S1C Crystal structure of the complex between the human RhoA and Rho-binding domain of human ROCKI X-RAY DIFFRACTION 2004-01-06 2009-02-24 2.60 0.22 0.26 7.5 0.71 (0.40)
3AGL Complex of PKA with the bisubstrate protein kinase inhibitor ARC-1039 X-RAY DIFFRACTION 2010-04-02 2011-07-13 2.10 0.2 0.24 6.9 0.49 (0.22)
3EG1 Crystal structure of the N114Q mutant of ABL-SH3 domain complexed with a designed high-affinity peptide ligand: implications for SH3-ligand interactions X-RAY DIFFRACTION 2008-09-10 2011-07-13 1.85 0.18 0.25 3.5 0.41 (0.16)
3EH9 Crystal structure of death associated protein kinase complexed with ADP X-RAY DIFFRACTION 2008-09-11 2009-04-28 1.70 0.18 0.22 0.30 (0.12)
1Z57 Crystal structure of human CLK1 in complex with 10Z-Hymenialdisine X-RAY DIFFRACTION 2005-03-17 2012-08-29 1.70 0.14 0.19 9.0 0.26 (0.10)
4G8L Active state of intact sensor domain of human RNase L with 2-5A bound X-RAY DIFFRACTION 2012-07-23 2012-11-14 2.80 0.23 0.26 7.0 0.75 (0.49)
4BDA Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2) X-RAY DIFFRACTION 2012-10-05 2013-06-26 2.60 0.18 0.24 0.80 (0.37)
2X81 STRUCTURE OF AURORA A IN COMPLEX WITH MLN8054 X-RAY DIFFRACTION 2010-03-05 2011-08-31 2.91 0.24 0.3 7.6 1.72 (0.62)
4NUS Rsk2 N-terminal kinase in complex with LJH685 X-RAY DIFFRACTION 2013-12-04 2014-11-12 2.39 0.19 0.23 0.58 (0.29)
2MFQ NMR solution structures of FRS2a PTB domain with neurotrophin receptor TrkB SOLUTION NMR 2013-10-18 2014-06-25
1LCJ SH2 (SRC HOMOLOGY-2) DOMAIN OF HUMAN P56-LCK TYROSINE KINASE COMPLEXED WITH THE 11 RESIDUE PHOSPHOTYROSYL PEPTIDE EPQPYEEIPIYL X-RAY DIFFRACTION 1994-12-12 2009-04-14 1.80 0.21
4I0S Crystal structure of spleen tyrosine kinase complexed with 2-(6-Chloro-1-methyl-1H-indazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid isopropylamide X-RAY DIFFRACTION 2012-11-19 2013-10-30 1.98 0.22 0.24 7.5 0.42 (0.18)
2UZD CRYSTAL STRUCTURE OF HUMAN CDK2 COMPLEXED WITH A THIAZOLIDINONE INHIBITOR X-RAY DIFFRACTION 2007-04-27 2009-02-24 2.72 0.21 0.27 7.0 0.96 (0.47)
1MFW STRUCTURE OF N-TERMINAL DOUBLECORTIN DOMAIN FROM DCLK: SELENOMETHIONINE LABELED PROTEIN X-RAY DIFFRACTION 2002-08-13 2009-02-24 1.60 0.13 0.18 5.0 0.22 (0.08)
3PE4 Structure of human O-GlcNAc transferase and its complex with a peptide substrate X-RAY DIFFRACTION 2010-10-25 2011-02-09 1.95 0.22 0.25 7.0 0.39 (0.19)
4I6F Selective & Brain-Permeable Polo-like Kinase-2 (Plk-2) Inhibitors that Reduce -Synuclein Phosphorylation in Rat Brain X-RAY DIFFRACTION 2012-11-29 2013-11-20 2.90 0.23 0.32 5.5 1.55 (0.65)
3SD5 Crystal Structure of PI3K gamma with 5-(2,4-dimorpholinopyrimidin-6-yl)-4-(trifluoromethyl)pyridin-2-amine X-RAY DIFFRACTION 2011-06-08 2012-02-29 3.20 0.21 0.26 8.5 1.38 (0.68)
3UVQ Human p38 MAP Kinase in Complex with a Dibenzosuberone Derivative X-RAY DIFFRACTION 2011-11-30 2013-07-17 2.20 0.24 0.32 6.1 0.70 (0.32)
3UIU Crystal structure of Apo-PKR kinase domain X-RAY DIFFRACTION 2011-11-06 2012-11-07 2.90 0.24 0.3 6.5 1.59 (0.62)
3GFW Crystal Structure of Human Dual Specificity Protein Kinase (TTK) in complex with a pyrolo-pyridin ligand X-RAY DIFFRACTION 2009-02-27 2011-07-13 5.6
3RWQ Discovery of a Novel, Potent and Selective Inhibitor of 3-Phosphoinositide Dependent Kinase (PDK1) X-RAY DIFFRACTION 2011-05-09 2011-12-28 2.55 0.19 0.26 7.0 0.96 (0.38)
4JT5 mTORdeltaN-mLST8-pp242 complex X-RAY DIFFRACTION 2013-03-22 2013-05-29 3.45 0.23 0.27 8.5 1.73 (0.85)
4MPC Crystal structure of pyruvate dehydrogenase kinase isoform 2 in complex with inhibitor PS2 X-RAY DIFFRACTION 2013-09-12 2014-03-05 1.70 0.2 0.22 4.6 0.32 (0.12)
3OW3 Discovery of dihydrothieno- and dihydrofuropyrimidines as potent pan Akt inhibitors X-RAY DIFFRACTION 2010-09-17 2010-11-24 1.90 0.16 0.21 8.0 0.35 (0.15)
4EH9 Human p38 MAP kinase in complex with NP-F11 and RL87 X-RAY DIFFRACTION 2012-04-02 2013-01-02 2.10 0.23 0.28 6.5 0.55 (0.25)
3TEI Crystal structure of human ERK2 complexed with a MAPK docking peptide X-RAY DIFFRACTION 2011-08-15 2012-10-31 2.40 0.2 0.24 6.5 0.68 (0.30)
4O38 Crystal structure of the human cyclin G associated kinase (GAK) X-RAY DIFFRACTION 2013-12-18 2014-01-01 2.10 0.16 0.2 7.0 0.42 (0.18)
4JJC Crystal structure of the Abl-SH3 domain at pH5 X-RAY DIFFRACTION 2013-03-07 2014-03-12 1.60 0.17 0.22 5.0 0.29 (0.10)