Summary
PDB 3DAB deposited: 2008-05-29 modified: 2009-02-24
Title Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain
Authors Czarna, A., Holak, T.A., Popowicz, G.M.
Method X-RAY DIFFRACTION
Structure factors resolution 1.9 rfactor 0.19657 rfree 0.2571
DPI 0.37 theoretical min: 0.18
Related PDB Entries 3DAC
Citations

The Mdmx oncoprotein has only recently emerged as a critical-independent to Mdm2-regulator of p53 activation. We have determined the crystal structure of the N-terminal domain of human Mdmx bound to a 15-residue transactivation domain peptide of human p53. The structure shows why antagonists of the Mdm2 binding to p53 are ineffective in the Mdmx-p53 interaction.

Cell Cycle 2008 Aug; 7(15):2441-2443 doi:

Cross References
Database source Identifier Description
PubMed 18677113
Biomolecule Structure Assembly Serial Assembly Type Conformational State Chains Ligands Atoms
3DAB/1 3DAB 1 dimer 0 2 0 882
3DAB/2 3DAB 2 dimer 0 2 0 855
3DAB/3 3DAB 3 dimer 0 2 0 877
3DAB/4 3DAB 4 dimer 0 2 0 838