PDB 3DAB deposited: 2008-05-29 modified: 2009-02-24
Title Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain
Authors Czarna, A., Holak, T.A., Popowicz, G.M.
Structure factors resolution 1.9 rfactor 0.19657 rfree 0.2571
DPI 0.37 theoretical min: 0.18
Related PDB Entries 3DAC

The Mdmx oncoprotein has only recently emerged as a critical-independent to Mdm2-regulator of p53 activation. We have determined the crystal structure of the N-terminal domain of human Mdmx bound to a 15-residue transactivation domain peptide of human p53. The structure shows why antagonists of the Mdm2 binding to p53 are ineffective in the Mdmx-p53 interaction.

Cell Cycle 2008 Aug; 7(15):2441-2443 doi:

Cross References
Database source Identifier Description
PubMed 18677113
Biomolecule Structure Assembly Serial Assembly Type Conformational State Chains Ligands Atoms
3DAB/1 3DAB 1 dimer 0 2 0 882
3DAB/2 3DAB 2 dimer 0 2 0 855
3DAB/3 3DAB 3 dimer 0 2 0 877
3DAB/4 3DAB 4 dimer 0 2 0 838