PDB 2P33 deposited: 2007-03-08 modified: 2009-02-24
Title Synthesis and SAR of Aminopyrimidines as Novel c-Jun N-Terminal Kinase (JNK) Inhibitors
Authors Alam, M., Beevers, R.E., Ceska, T., Davenport, R.J., Dickson, K.M., Fortunato, M., Gowers, L., Haughan, A.F., James, L.A., Jones, M.W., Kinsella, N., Lowe, C., Meissner, J.W., Nicolas, A.L., Perry, B.G., Phillips, D.J., Pitt, W.R., Platt, A., Ratcliffe, A.J., Sharpe, A., Tait, L.J.
Structure factors resolution 2.4 rfactor 0.253 rfree 0.304
DPI 0.84 theoretical min: 0.39

The development of a series of novel aminopyrimidines as inhibitors of c-Jun N-terminal kinases is described. The synthesis, in vitro inhibitory values for JNK1, JNK2 and CDK2, and the in vitro inhibitory value for a c-Jun cellular assay are discussed.

Bioorg.Med.Chem.Lett. 2007 Jun; 17(12):3463-3467 doi:10.1016/j.bmcl.2007.03.078

Cross References
Database source Identifier Description
ChEMBL Document CHEMBL1139954
PubMed 17459703 BMCLE8
Biomolecule Structure Assembly Serial Assembly Type Conformational State Chains Ligands Atoms
2P33/0 2P33 0 monomer 0 1 1 2527