Summary
PDB 2ICW deposited: 2006-09-13 modified: 2009-02-24
Title Crystal structure of a complete ternary complex between TCR, superantigen, and peptide-MHC class II molecule
Authors Guo, Y., Jones, L.L., Kranz, D.M., Li, H., Li, Z., Mourad, W., Wang, L., Zhao, Y.
Method X-RAY DIFFRACTION
Structure factors resolution 2.41 rfactor 0.242 rfree 0.288
DPI 0.52 theoretical min: 0.37
Citations

'Superantigens' (SAgs) trigger the massive activation of T cells by simultaneous interactions with MHC and TCR receptors, leading to human diseases. Here we present the first crystal structure, at 2.5-A resolution, of a complete ternary complex between a SAg and its two receptors, HLA-DR1/HA and TCR. The most striking finding is that the SAg Mycoplasma arthritidis mitogen, unlike others, has direct contacts not only with TCR Vbeta but with TCR Valpha.

Nat.Struct.Mol.Biol. 2007 Feb; 14(2):169-171 doi:10.1038/nsmb1193

Cross References
Database source Identifier Description
PubMed 17220897
Biomolecule Structure Assembly Serial Assembly Type Conformational State Chains Ligands Atoms
2ICW/1 2ICW 1 hexamer 0 6 0 6297
2ICW/2 2ICW 2 hexamer 0 6 0 6347