PDB 1PMV deposited: 2003-06-11 modified: 2009-02-24
Title The structure of JNK3 in complex with a dihydroanthrapyrazole inhibitor
Authors Becker, J.W., Lisnock, J., LoGrasso, P.V., Patel, S.B., Scapin, G.
Structure factors resolution 2.5 rfactor 0.218 rfree 0.282
DPI 0.91 theoretical min: 0.40
Related PDB Entries 1PMN 1PMQ 1PMU 4Z9L

The c-Jun terminal kinases (JNKs) are members of the mitogen-activated protein (MAP) kinase family and regulate signal transduction in response to environmental stress. Activation of JNK3, a neuronal-specific isoform, has been associated with neurological damage, and as such, JNK3 may represent an attractive target for the treatment of neurological disorders. The MAP kinases share between 50% and 80% sequence identity. In order to obtain efficacious and safe compounds, it is necessary to address the issues of potency and selectivity. We report here four crystal structures of JNK3 in complex with three different classes of inhibitors. These structures provide a clear picture of the interactions that each class of compound made with the kinase. Knowledge of the atomic interactions involved in these diverse binding modes provides a platform for structure-guided modification of these compounds, or the de novo design of novel inhibitors that could satisfy the need for potency and selectivity.

Chem.Biol. 2003 Aug; 10(8):705-712 doi:10.1016/S1074-5521(03)00159-5

Cross References
Database source Identifier Description
PubMed 12954329 CBOLE2
Biomolecule Structure Assembly Serial Assembly Type Conformational State Chains Ligands Atoms
1PMV/0 1PMV 0 monomer 0 1 1 2660