Summary
PDB 1BG1 deposited: 1998-06-03 modified: 2009-02-24
Title TRANSCRIPTION FACTOR STAT3B/DNA COMPLEX
Authors Becker, S., Groner, B., Muller, C.W.
Method X-RAY DIFFRACTION
Structure factors resolution 2.25 rfactor 0.246 rfree 0.301
DPI 0.69 theoretical min: 0.32
Citations

STAT proteins are a family of eukaryotic transcription factors that mediate the response to a large number of cytokines and growth factors. Upon activation by cell-surface receptors or their associated kinases, STAT proteins dimerize, translocate to the nucleus and bind to specific promoter sequences on their target genes. Here we report the first crystal structure of a STAT protein bound to its DNA recognition site at 2.25 A resolution. The structure provides insight into the various steps by which STAT proteins deliver a response signal directly from the cell membrane to their target genes in the nucleus.

Nature 1998 Jul; 394(6689):145-151 doi:10.1038/28101

Cross References
Database source Identifier Description
PubMed 9671298 NATUAS
Biomolecule Structure Assembly Serial Assembly Type Conformational State Chains Ligands Atoms
1BG1/1 1BG1 1 tetramer 0 4 0 9118