Summary
PDB 1AD6 deposited: 1997-02-21 modified: 2009-02-24
Title DOMAIN A OF HUMAN RETINOBLASTOMA TUMOR SUPPRESSOR
Authors Cho, Y., Kim, H.Y.
Method X-RAY DIFFRACTION
Structure factors resolution 2.3 rfactor 0.201 rfree 0.24
DPI 0.65 theoretical min: 0.27
Citations

The pocket region of retinoblastoma tumour suppressor (Rb) is essential for tumour suppressing activity. The Rb pocket is primarily composed of two domains, A and B. We have determined the X-ray crystal structure of domain A (residues 378-562) at 2.3 A resolution. Domain A consists of nine alpha-helices. The overall arrangement of helices in domain A is remarkably similar to the cyclin-box folds found in the crystal structures of cyclin A and TFIIB. This structure, along with domain B which is predicted to be homologous to the cyclin-box, suggests that the Rb pocket is composed of two cyclin-box fold domains. We present the structural/functional features of the Rb pocket, and the potential binding region for cellular or viral proteins within domain A.

Nat.Struct.Biol. 1997 May; 4(5):390-395 doi:10.1038/nsb0597-390

Cross References
Database source Identifier Description
PubMed 9145110 NSBIEW
Biomolecule Structure Assembly Serial Assembly Type Conformational State Chains Ligands Atoms
1AD6/0 1AD6 0 monomer 0 1 0 1363